Journal article
Biocompatible porous polyester-ether hydrogel scaffolds with cross-linker mediated biodegradation and mechanical properties for tissue augmentation
B Ozcelik, J Palmer, K Ladewig, PF Marina, GW Stevens, K Abberton, WA Morrison, A Blencowe, GG Qiao
Polymers | MDPI | Published : 2018
Abstract
Porous polyester-ether hydrogel scaffolds (PEHs) were fabricated using acid chloride/alcohol chemistry and a salt templating approach. The PEHs were produced from readily available and cheap commercial reagents via the reaction of hydroxyl terminated poly(ethylene glycol) (PEG) derivatives with sebacoyl, succinyl, or trimesoyl chloride to afford ester cross-links between the PEG chains. Through variation of the acid chloride cross-linkers used in the synthesis and the incorporation of a hydrophobic modifier (poly(caprolactone) (PCL)), it was possible to tune the degradation rates and mechanical properties of the resulting hydrogels. Several of the hydrogel formulations displayed exceptional ..
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
Andrea O'Connor (Department of Chemical and Biomolecular Engineering, The University of Melbourne) for use of facilities, Phong Tran (Department of Chemical and Biomolecular Engineering, The University of Melbourne) for assistance with in vitro cell viability assays, Mr. Roger Curtain (Advanced Microscopy Facility, Bio21) for assistance with scanning electron microscopy, O'Brien Institute for providing facilities for in vivo studies and histological analysis. The authors acknowledge The University of Melbourne and the Australian Research Council (ARC) for scholarship and fellowship support (BO: Melbourne Research Scholarship; GGQ: ARC Future Fellowship FT (FT110100411); KL: ARC Super Science Fellowship (FS110200025)); W.A.M: NHMRC project Grant: GNT1064786.